Effect of paricalcitol and enalapril on renal inflammation/oxidative stress in atherosclerosis

Figure 2 Effect of paricalcitol and enalapril alone and in combination for 16-wk on mono and combination for 16-wk on renal malondialdehyde and glutathione levels in ApoE-deficient atherosclerotic mice. There was a significant (P < 0.001) increase in the renal MDA levels in atherosclerotic mice compared to wild type control (group 5). Paricalcitol (n = 6) and Enalapril (n = 6) alone significantly (P < 0.05 and P < 0.05) reduced aortic malondialdehyde (MDA) levels. However combination of the two (n = 6) decreased greater and significant (P < 0.01) aortic MDA levels than either drug alone in atherosclerotic mice (n = 6). There was a significant (P < 0.001) decrease in aortic glutathione (GSH) levels in atherosclerotic mice compared to wild type control (group 5). Paricalcitol (n = 6) and enalapril (n = 6) alone significantly (P < 0.05) increased aortic GSH levels. However combination of the two (n = 6) increased greater and significant (P < 0.01) aortic GSH levels than either drug alone in atherosclerotic mice (n = 6).