Copyright
©The Author(s) 2015.
World J Biol Chem. Aug 26, 2015; 6(3): 110-120
Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.110
Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.110
Figure 1 Hyaluronan synthesis.
Uridine diphosphate (UDP)-linked sugar substrates, glucuronic acid (GlcA) and N-acetylglucosamine (GlcNAc), are sequentially added to the reducing end of the growing HA chain at the cytoplasmic aspect of the cell membrane through the action of hyaluronan synthase (HAS). The resulting sugar polymer is extruded into the extracellular matrix surrounding the cell.
- Citation: Triggs-Raine B, Natowicz MR. Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism. World J Biol Chem 2015; 6(3): 110-120
- URL: https://www.wjgnet.com/1949-8454/full/v6/i3/110.htm
- DOI: https://dx.doi.org/10.4331/wjbc.v6.i3.110