Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation

Figure 4 Schematic depiction of box H/ACA RNA. The core components of a box H/ACA RNP, a box H/ACA RNA and four proteins (Nhp2, Nop 10, Gar1 and Cbf5), are shown. An RNA substrate paired with the two internal loops of the box H/ACA RNA is also shown. The arrows indicate the target nucleotides for pseudouridylation. The H box (5'-ANANNA-3') and ACA box (5'-ACA-3') are indicated.