Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation

Figure 3 Schematic representation of uridine-to- pseudouridine isomerization. Pseudouridine is a rotational isomer of uridine, in which the N-C glycosidic bond is broken to form the C-C bond. This results in the creation of an extra hydrogen bond donor (d), while the number of hydrogen bond acceptors (a) is unchanged.