FoxO3a and disease progression

Figure 1 Forkhead box O3a target genes. Forkhead box O (FoxO)3a transcriptionally activates several target genes. FoxO3a binds to the promoter of apoptosis inducing genes, such as Bim, FasL and TRAIL, and to the promoter of cell cycle inhibitors, such as p27 and p21. FoxO3a also activates autophagy genes Gabarapl1, ATG12, etc. A recent study showed that FoxO3a also participates in the activation of stress response genes, such as MnSOD and catalase in response to oxidative stress.