Mnk kinase pathway: Cellular functions and biological outcomes

Figure 2 Effectors of the Mnk kinases. The Mnk kinases can regulate multiple biological processes by phosphorylating multiple substrates. Mnk mediated phosphorylation of eIF4E and eIF4G can play an important role in mediating cap dependent translation. The Mnk substrates hnRNPA1 and PSF play an important role in mediating the translation of AU rich elements containing mRNAs such as the TNF-α mRNA. The Mnk kinases also phosphorylate cPLA2 which plays an important role in arachidonate release from platelets. TNF-α: Tumor necrosis factor-α; eIF4G: Eukaryotic initiation factor 4G; hnRNPA1: Heterogenous nuclear ribonucleoprotein A1; cPLA2: Cytosolic phospholipase A2.