Critical role of bicarbonate and bicarbonate transporters in cardiac function

Table 1 Relative mRNA levels for the Slc4a and Slc26a anion transporters in mouse heart

SLC4A family			SLC26A family
Gene symbol	Transporter name and major function(s);alternate names	Average ± SE	Gene symbol	Transporter name and major function(s);alternate names	Average ± SE
Slc4a1	AE1 Cl-/HCO3- exchanger; Band 3	0.2 ± 0.05	Slc26a1	SAT1 sulfate/anion exchanger; Slc26a1	0.34 ± 0.07
Slc4a2	AE2 Cl-/HCO3- exchanger	12.57 ± 0.28	Slc26a2	DTDST sulfate/anion exchanger; Slc26a2	2.98 ± 0.17
Slc4a3	AE3 Cl-/HCO3- exchanger	85.7 ± 0.64	Slc26a3	DRA Cl-/HCO3-, exchanger; Slc26a3	0.64 ± 0.05
Slc4a4	NBCe1 Na+/HCO3- cotransporter; NBC1	9.45 ± 0.25	Slc26a4	Pendrin Cl-/HCO3- exchanger; Slc26a4	0.02 ± 0.01
Slc4a5	NBCe2 Na+/HCO3- cotransporter; NBC4	0.003 ± 0.002	Slc26a6	PAT1 Cl-/HCO3-, Cl-/formate exchanger; Slc26a6	4.56 ± 0.26
Slc4a7	NBCn1 Na+/HCO3- cotransporter; NBC2; NBC3	4.24 ± 0.05	Slc26a7	Slc26a7 Cl-/HCO3- exchanger, Cl- channel; TAT1	0.15 ± 0.04
Slc4a8	NDCBE Na+-driven Cl-/HCO3- exchanger; Slc4a8	0.73 ± 0.04	Slc26a9	Slc26a9 Cl-/HCO3- exchanger, Cl- channel	0.01 ± 0.01
Slc4a9	AE4 Cl-/HCO3- exchanger	0.02 ± 0.01	Slc26a10	Slc26a10, transporter function unknown	31.66 ± 2.55
Slc4a10	NBCn2 Na+/HCO3- cotransporter	0.02 ± 0.003	Slc26a11	Slc26a11 anion exchanger, Cl- channel; KBAT	1.15 ± 0.14

Relative mRNA expression levels were determined using RNA from 4-month-old male FVB/N mouse hearts (n = 4) as described previously[51]. Values are RPKM (reads per kilobase per million mapped reads) ± SE and are a measure of the relative abundance of specific gene transcripts[53]. For some Slc26a transporters, ion transport specificities are more complex than indicated; see Alper and Sharma[9].