KAPtain in charge of multiple missions: Emerging roles of KAP1

Table 2 Transcription factors involved in KAP1-regulated gene expression

Transcription factor	KAP1 function	Ref.
Myc	KAP1 is involved in MM-1 and HDAC1 complex to suppress c-Myc transcription activity	[10,11]
ZNF160	KAP1 interacts with ZNF160 and recruits HDAC to downregulate TLR4 in intestinal epithelial cells	[79]
Oct3/4	KAP1 is potentially involved in regulating pluripotency of embryonic stem cells	[78]
E2F1	KAP1 suppresses E2F1 transcriptional activity and inhibits E2F1 acetylation in an HDAC1 dependent manner	[13]
p53	KAP1 is associated with MDM2-p53-HDAC1 complex and inhibits p53 acetylation and promotes p53 degradation	[75]
p53	MAGE proteins stabilize KAP1-p53 complex to decrease acetylation and promote degradation of p53	[80]
p53	KAP1 ubiquitinates p53 for proteasome degradation	[23]
IRF7	KAP1 sumolyates IRF7 and suppresses IRF7 transcriptional activity in IFN production	[24]
ZBRK1	KAP1 interacts with ZBRK1 to repress Gadd45α and p21 gene expression	[16,17,69]
HIF-1α	VHLaK potentially recruits KAP1 to HIF-1α complex to suppress HIF-1α downstream gene expression	[72]
Nrf2	KAP1 interacts with Nrf2 and facilitates Nrf2 transactivation activity	[76]
STAT3	KAP1 interacts with STAT3 to suppress STAT3 transcriptional activity	[82]
STAT1	KAP1 interacts with STAT1 to suppress STAT1 transcriptional activity	[50]
ZNF689	ZNF689 potentially recruits KAP1 to suppress autophagy-gene-targeting miRNAs	[71]
FOXP3	KAP1 is recruited by FIK in FOXP3-FIK-KAP1 complex to suppress FOXP3-target genes	[74]
NFκB	KAP1 is associated with NFκB and negatively regulates it acetylation and transcriptional activity	[51]
SRY	KAP1 is recruited by KRAB-O to SRY binding sites for gene regulation	[68,73]
ZFP57	ZFP57 and KAP1 are associated with NP95-DNMT complex for maintaining DNA methylation at imprinting control region	[59,61,62]

VHLaK: VHL-associated KRAB-A domain-containing protein; HDAC: Histone deacetylase; DNMT: DNA methyltransferase.