Functional analysis of human Na+/K+-ATPase familial or sporadic hemiplegic migraine mutations expressed in Xenopus oocytes

Figure 5 Reciprocal time constants of transient currents. A-E: Voltage dependence of reciprocal time constants τ-1 from ouabain-sensitive transient currents of RD-WT enzyme (E) and the mutants G900R (A), E902K (B), D999H (C) and K1003E (D) under K⁺-free Na⁺/Na⁺ exchange conditions. The fit of a polynomial function to RD-WT values is superimposed as a dotted line. An “a” indicates that the data point was significantly different from the RD-WT data (^aP < 0.05 vs RD-WT, Student’s t-test). Data are means ± SE from 5-21 oocytes of at least three batches.