Role of 3’-untranslated region translational control in cancer development, diagnostics and treatment

Figure 2 Models of RNA binding protein and miRNA interplay targeting the same mRNA. A, B: Competitive interaction. A: RBP stabilizes the secondary structure in 3’UTR, and prevents miRNA binding; B: RBP competes with miRNA for the same binding site; C, D: Cooperative interaction; C: RBP facilitates miRNA function by opening secondary structure in 3’UTR and liberating its binding site; D: RBP directly interacts with RISC (RNA-induced silencing complex) complex, stabilizing binding of the latter. RBPs: RNA binding proteins; 3’UTR: 3’-untranslated region.