Systems biology unravels interferon responses to respiratory virus infections

Figure 1 Interferon activation. NLRX1 : Nucleotide-binding oligomerization domain, leucine rich repeat containing X1; TRIM25: Tripartite motif-containing 25; MITA/STING: Mediator of IRF3 activation/stimulator of interferon genes protein; TRIM11: Tripartite motif containing 11; RNF11: Ring finger protein 11; TRIP: Thyroid receptor-interacting protein; DUBA: Deubiquitinating enzyme A; RLRs: RIG-like receptors; TLRs: Toll-like receptors; IFIT3: Interferon-inducible transmembrane protein 3; MAVS: Mitochondrial anti-viral signaling protein; NLRC5: Nod-like receptor C5; PCBP2: Poly(rC)-binding protein 2; PSMA7: Proteasome subunit alpha type-7; TBK1: Tank binding kinase; IKKe: Inhibitor of nuclear factor kappa-B kinase; IRFs: Interferon regulatory factors; WNT/CTNNB1: Wnt/beta-catenin.