MicroRNA signature and function in retinal neovascularization

Figure 2 Overview of major angiogenic and antiangiogenic miRNAs and their targets in promoting or suppressing retinal neovascularization. VEGF: Vascular endothelial growth factor; IGFs: Insulin-like growth factors; HIF-1α: Hypoxia-inducible factor 1α; bFGF: Basic fibroblast growth factor; PDGF: Platelet derived growth factor; IL-8: Interleukin 8; MMP: Matrix metalloproteinase; ICAM-1: Intercellular adhesion molecule-1; TNF-α: Tumour necrosis factor-alpha; MAPK: Mitogen-activated protein kinase.