Lipidomic mass spectrometry and its application in neuroscience

Table 2 Select performance parameters of some commercially available mass spectrometers

Parameter	TSQ quantum access max	TSQquantiva	LTQ-orbitrap velos	Qq-ToF	Synapt G2-S HDMS	Q-exactive	Agilent 6540	Orbitrap fusion tribrid
Acquisition rate	5000 amu/s	15000 amu/s	1/s@60000 RP	3/s@30000 RP	30/s MS or MSe mode	13/s@17500	20 MS/s	15/sec@15000
			3/s@15000 RP		2000/s IMS mode	1.5/s@140000	10 MS2/s
Linear dynamic range	5 orders	6 orders	5-6 orders	2-3 orders	> 5 orders In-spectrum1	> 5 orders	5 orders	> 5 orders
Mass accuracy	0.1 Da	0.1 Da	< 3 ppm MS	< 5 ppm Full scan w/Lock Mass	< 1 ppm MS MSe or MS/MS	< 1 ppm	< 1 ppm MS	< 1 ppm
			< 3 ppm MSn	> 100 ppm MS/MS			< 2 ppm MS2	< 1 ppm MSn
			(no lock mass)
Resolution	0.4 Da FWHM	0.2 Da FWHM	> 100000 RP	Up to 30000 RP	Up to 40000RP	140000	> 15000 RP@ 1522	450000
Sensitivity	Sub-femto-mol	Atto-mol	Sub atto-mol	Sub femto-mol	Approximately 10 charges at the detector	Atto-mol	Femto-mol	Sub atto-mol

¹At full resolution and maximum acquisition rate. ToF: Time of flight; LTQ: Linear trap quadropole; TSQ: Triple stage quadrupole; HDMS: High definition mass spectrometry; MS: Mass spectrometry; IMS: Ion mobility spectometry.