Lipidomic mass spectrometry and its application in neuroscience

Table 1 Comparison of leading mass spectrometers for lipidomics

	Resolution	Mass range(m/z)	Mass accuracy(ppm)
ToF			2-5 typical
Waters LCT premier	10000	18000	NA
Agilent LC/ToF	> 22000	50-20000	< 1
Bruker microToF	10000	3000	NA
QToF			Same as ToF
Agilent 6540	> 40000	50-10000	< 1
Waters QToF ultima	17500	32000	1
Waters QToF micro	5000	20000	1
Bruker max is 4G	> 60000	10000	< 1
LTQ velos	3000	4000	0.1 Da
LTQ-orbitrap velos	> 100000	4000	< 2
TSQ quantum access max	0.4 (FWHM)	3000	0.1 Da
TSQ quantiva	0.2 (FWHM)	1850	0.1 Da
Q-exactive	140000	6000	< 1
Orbitrap fusion tribrid	450000	4000	< 1
Synapt G2-HDMS	40000	32000 (1000001)	< 1
Synapt G2S-HDMS	20000	32000 (1000001)	Approx- imately 2

¹When fitted with a quadrupole. m/z: Mass to charge ratio, ppm: Parts per million; LCT: Liquid chromatograph; LTQ: Linear trap quadropole; TSQ: Triple stage quadrupole; HDMS: High definition mass spectrometry; FWHM: Full width at half maximum; ToF: Time of flight; NA: Not available.