Update on vascular endothelial Ca2+ signalling: A tale of ion channels, pumps and transporters

Table 4 Pattern of expression of transient receptor potential melastatin channels in vascular endothelial cells as detected by reverse transcription/polymerase chain reaction, Western blotting, and in situ hybridization

	TRPM1	TRPM2	TRPM3	TRPM4	TRPM5	TRPM6	TRPM7	TRPM8
PCa/PNa and conductance (pS)[202]	NM, NM	0.5-1.6, 52-80	0.1-10, 65 (Ca2+)-130	Not permeable, 25	Not permeable, 16-25	PCa/PNa~6, NM	3, 40-105	1-3, 83
Human Pulmonary artery ECs[320]	+(RT-PCR)	+/-(RT-PCR) +(WB)	+(RT-PCR)	+(RT-PCR)	-(RT-PCR)	+(RT-PCR)	+(RT-PCR)	+(RT-PCR)
Human umbilical vein ECs[325,327,328]				+(RT-PCR, WB)		-(RT-PCR)	+(RT-PCR, WB)
Mouse aortic ECs[329]				+(RT-PCR, WB)			+(RT-PCR)
Human dermal microvascular ECs[327]							+(RT-PCR, WB)
Mouse cerebral microvascular ECs	-(RT-PCR)	+(RT-PCR)	+(RT-PCR)	+(RT-PCR)	-(RT-PCR)	-(RT-PCR)	+(RT-PCR)	-(RT-PCR)
Mouse cardiac microvascular ECs[8]		+(RT-PCR, WB)					+(RT-PCR)
Rat cerebral artery ECs[311]				+(RT-PCR)		+(RT-PCR)	+(RT-PCR)
Rat spinal cord capillary ECs[324]				+(ISH)
Rat mesenteric artery ECs[312]							+(RT-PCR)

RT-PCR: Reverse transcription/polymerase chain reaction; WB: Western blotting; IHC: Immunohistochemistry; ISH: In situ hybridization; NM: Not measured; ECs: Endothelial cells.