Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges

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Apr 26, 2012 (publication date) through Jan 9, 2025

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Apr 26, 2012; 3(4): 73-92
Published online Apr 26, 2012. doi: 10.4331/wjbc.v3.i4.73

Table 2 Transport mechanisms for proteins from systemic circulation across capillary endothelia[22]

Type of capillary endothelium	Barrier/transport mechanism	Particle size subject to passage	Typical tissues
Continuous (non-fenestrated)	Basal lamina membrane supported by collagen	50-110 nm	Muscle, central nervous system, bone, skin, cardiac muscle
Fenestrated	Large pores, open fenestrae, intracellular junctions, basal lamina	50-800 nm	Renal glomeruli, intestinal villi, synovial tissue, endocrine glands, choroid plexus (brain)
Discontinuous (sinusoidal)	Large pores (fenestrae), pinocytotic vesicles	1000-10 000 nm	Liver, spleen, bone marrow, postcapillary venules of lymph nodes

Citation: Vugmeyster Y, Xu X, Theil FP, Khawli LA, Leach MW. Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges. World J Biol Chem 2012; 3(4): 73-92
URL: https://www.wjgnet.com/1949-8454/full/v3/i4/73.htm
DOI: https://dx.doi.org/10.4331/wjbc.v3.i4.73