Transglutaminase inhibition: A therapy to protect cells from death in neurodegeneration?

Figure 1 Possible mechanisms responsible for protein aggregate formation catalyzed by transglutaminases. Insoluble aggregates can be formed both by the acyl transfer between the γ-carboxamide group of a protein/polypeptide glutaminyl residue and the ε-amino group of a protein/polypeptide lysyl residue, and by the attachment of a polyamine to the γ-carboxamide of a glutaminyl residue. TGs: Transglutaminases.