p53 in stem cells

Figure 2 p53 suppresses self-renewal and promotes differentiation of adult stem cells. A: In mammary gland stem cells, p53 promotes asymmetric cell division, resulting in an increased number of differentiated cells and a reduction in the stem cell pool; B: In mesenchymal stem cells (MSCs), p53 suppresses proliferation and self-renewal and reduces differentiation by suppressing runx2, osterix and pparγ; C: p53 supports quiescence of hematopoietic stem cells and reduces proliferation. This effect is mediated by transcriptional activation of gf1, necdin and p21 (Top). In response to DNA damage, p53 enhances the death of severely damaged cells by cell competition (below).