Vasoactive intestinal peptide signaling axis in human leukemia

Figure 7 Working model for Ikaros mediated regulation of vasoactive intestinal peptide receptor 1 expression. IK-5 overexpression results in the upregulation of vasoactive intestinal peptide receptor (VPAC)1 steady-state levels in resting Hut-78 cells. The DNA binding activity of Ikaros therefore can alter the expression of growth modulating genes like VPAC1 in a direct (binding to the VPAC1 gene) or indirect mechanism (regulating a repressor/activator that binds the VPAC1 gene). We predict VPAC1 silencing will occur in activated IK-5 overexpressing cells.