Roles of sphingosine 1-phosphate on tumorigenesis

doi:10.4331/wjbc.v2.i2.25

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Feb 26, 2011 (publication date) through Jan 1, 2025

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Feb 26, 2011; 2(2): 25-34
Published online Feb 26, 2011. doi: 10.4331/wjbc.v2.i2.25

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Figure 1 Sphingolipid structure and metabolism. All sphingolipids contain a long chain base. Sphingomyelin (SM) is metabolized to ceramide by sphingomyelinase. Ceramide is further metabolized to sphingosine and sphingosine 1-phosphate (S1P) by ceramidase and sphingosine kinases (SphKs), respectively. Subsequently, S1P is irreversibly degraded to hexadecenal and ethanolamine phosphate by S1P ligase (SPL). S1P can be recycled to sphingosine and then ceramide by S1P phosphatase (S1PP) and ceramide synthase, respectively.

Citation: Huang YL, Huang WP, Lee H. Roles of sphingosine 1-phosphate on tumorigenesis. World J Biol Chem 2011; 2(2): 25-34
URL: https://www.wjgnet.com/1949-8454/full/v2/i2/25.htm
DOI: https://dx.doi.org/10.4331/wjbc.v2.i2.25