Regulation of heme oxygenase expression by alcohol, hypoxia and oxidative stress

Figure 4 MnSOD knockout mice (Sod2^+/-) and heme oxygenase expression. Heme oxygenase (HO)-1 (A) and HO-2 (B) mRNA expression in the brain (lanes 1 and 2), liver (lanes 3 and 4) and duodenum (lanes 5 and 6) of Sod2^+/- mice fed with plain water as control (lanes 1, 3 and 5) or 10% ethanol in drinking water (lanes 2, 4 and 6) for 7 d was measured by real-time polymerase chain reaction. HO expression in alcohol-treated Sod2^+/- mice was expressed as fold expression of that in control Sod2^+/- mice fed with plain water. ^bP < 0.01.