Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain

Figure 7 Dose-response graph, IC₅₀ and molecular structure of the 5 most active compounds (IC₅₀ < 40 μmol/L) on conversion of DQ™-gelatin and a fluorescent peptide by matrix metalloproteinase-9. The results obtained with the DQ™-gelatin assay (including the IC₅₀s) are shown in the left column. The chemical structures are shown in the central column. Data with the fluorescent peptide are shown in the right column.