Molecular genetics of early-onset colorectal cancer

Table 2 Differentially expressed transcripts in early-onset colorectal cancer

Gene(s)	Description
MYC	Proto-oncogenic transcription factor, increased in EOCRC tumors vs normal samples[50,69]
ASCL2	Transcription factor that promotes intestinal stem cells, increased expression in younger CRC[69]
ALDH1A1	Protein involved in cancer cell stemness, expressed higher in EOCRC tumors[88]
PEG10	Promotes proliferation and invasion, increased in EOCRC tumor vs normal and EOCRC vs LOCRC[70]
miR-143, miR-125b	miRNAs, under-expressed in EOCRC tumor vs normal[76]
miR-106a	miRNA, overexpressed in EOCRC tumor vs normal[76]
hsa-miR-4304, hsa-miR-513a-5p, hsa-miR-628-3p, hsa-miR-194-3p, hsa-miR-193a-5p, hsa-miR-210, and hsa-miR-4453	miRNAs uniquely overexpressed in EOCRC compared with LOCRC and normal tissues[75]
SAA1, C7, CFD	Immune genes differentially expressed in EOCRC vs LOCRC tumors[73]
NRF2	Protein involved in oxidative stress and inflammation, expressed higher in EOCRC vs LOCRC[74]

CRC: Colorectal cancer; EOCRC: Early-onset colorectal cancer; LOCRC: Later-onset colorectal cancer; miRNA: microRNAs.