LIN28A: A multifunctional versatile molecule with future therapeutic potential

Table 2 Clinical relevance of LIN28A in certain cancers[25]

Tissue	Primary tumour	Clinical Relevance of LIN28A
Breast	HER2 + tumour	Overexpression correlated with HER2 + tumours
Colon	Primary adenocarcinoma	Expressed in approximately 30% tumours
Kidney	Primary Wilms’ tumour	Overexpressed in late stage
Lung	Small cell lung cancer	Loss increases let-7 levels; inhibits cell cycle
Oesophagus	Primary human tumour	Expression linked to metastasis and poor prognosis
Ovary	Primary ovarian tumour	Knockdown increases let-7 expression

Citation: Thornton JE, Gregory RI. How does Lin28 Let-7 control development and disease? Trends Cell Biol 2012; 22: 474-482. Copyright© The Authors 2012. Published by Elsevier Ltd. All rights reserved.