Remission is not maintained over 2 years with hematopoietic stem cell transplantation for rheumatoid arthritis: A systematic review with meta-analysis

Figure 4 Potential areas of future research to optimize hematopoietic stem cell transplantation treatment for rheumatoid arthritis. Q1 is to evaluate whether stem cell rescue is necessary after high dose immune ablation; Q2 is to assess the ideal source of hematopoietic stem cells (HSCs); Q3 deals with either autologous or allogeneic source; Q4 deals with the need for T cell depletion from the harvested material; Q5 probes into the ideal conditioning regimen; and Q6 evaluates the ideal timing of HSC transplantation in the course of the disease. HSC: Hematopoietic stem cell.