Remission is not maintained over 2 years with hematopoietic stem cell transplantation for rheumatoid arthritis: A systematic review with meta-analysis

Table 3 Hematopoietic stem cell transplant protocol in the included studies (n = 17)

Sl. No	Ref.	Mobilization regimen	Graft manipulation	HSC selection	Conditioning regimen
1	Joske et al[33]	CYC 4 g/m2, G-CSF 10 µg/kg	Leukapheresis	CD 34 +ve selection	CYC 200mg/kg
2	Durez et al[34]	CYC 1.5 g/m2, etoposide 300 mg/m2, G-CSF 5 µg/kg	Leukapheresis	CD 34 +ve selection	CYC 60 mg daily and busulfan 4 mg daily
3	Burt et al[26]	CYC, G-CSF	Leukapheresis	CD 34 +ve selection	CYC 200 mg/kg, ATG 90 mg/kg
4	Snowden et al[27]	CYC 100-200 mg/kg, G-CSF 5 µg/kg	Leukapheresis	CD34 +ve selection	CYC 100 mg/kg or 200 mg/kg
5	Burt et al[25]	CYC 2 g/m2, G-CSF	Leukapheresis	CD34 +ve selection	CYC 200 mg/kg, ATG 90 mg/kg
6	Kim et al[35]	CYC 4 g/m², G-CSF 5 µg/kg	Leukapheresis	CD 34 +ve selection	CYC 200 mg/kg, ATG 90 mg/kg
7	Tyndall et al[29]	CYC, G-CSF	Leukapheresis	NR	CYC 200 mg/kg, ± ATG 90 mg/kg, ± Busulfan
8	van Laar et al[28]	CYC 4 g/m², G-CSF 10 µg/kg	Leukapheresis	CD34 +ve selection	CYC 200 mg/kg
9	Verburg et al[30]	CYC 4 g/m², G-CSF 10 µg/kg	Leukapheresis	CD 34 +ve selection	CYC 200 mg/kg
10	Bingham et al[11]	CYC 2 g/m2, G-CSF	Leukapheresis	CD 34 +ve selection	CYC 200 mg/kg
11	Pavletic et al[31]	CYC 2 g/m2, G-CSF	Leukapheresis	CD34 +ve selection	CYC 200 mg/kg, ATG 90 mg/kg
12	Moore et al[13]	CYC 200 mg/kg, G-CSF 10 µg/kg	Leukapheresis	CD34 +ve selection (18) / No selection (15)	CYC 200 mg/kg
13	Burt et al[36]	NA	NA	CD 34 +ve selection	CYC 150 mg/kg, fludarabine 125 mg/m2, alemtuzumab 20 mg
14	Snowden et al[15]	CYC 200 mg/kg, G-CSF 5- 10 µg/kg	Leukapheresis	CD 34 +ve selection (45) / No selection (28)	CYC 200 mg/kg
15	Verburg et al[32]	CYC 200 mg/kg, G-CSF	Leukapheresis	CD 34 +ve selection	CYC 200 mg/kg
16	Teng et al[9]	NA	NA	CD 34 +ve selection	CYC 200 mg/kg
17	Silva et al[12]	NA	NA	CD 34 +ve selection	Fludarabine 30 mg/m²/d, melphalan 140 mg/m²/d, alemtuzumab 0.2 mg/kg/d or fludarabine 30 mg/m²/d, treosulfan 14 mg/m²/d, alemtuzumab 0.2 mg/kg/d

ATG: Anti-thymocyte globulin; CD: Cluster differentiation: CYC: Cyclophosphamide; G-CSF: Granulocyte colony stimulating factor; HSC: Hematopoietic stem cell; NA: Not applicable; NR: Not reported.