Remission is not maintained over 2 years with hematopoietic stem cell transplantation for rheumatoid arthritis: A systematic review with meta-analysis

Table 2 General characteristics of the included studies (n = 17)

Sl. No	Ref.	Year	Study design	Indication	Sample size	Age (yr)	Source (Autologous/allogenic)	Mean follow-up (mo)
1	Joske et al[33]	1997	Case report	Failed DMARDs	1	46	Autologous	6
2	Durez et al[34]	1998	Case report	Failed DMARDs	1	22	Autologous	10
3	Burt et al[26]	1998	Prospective study	Failed DMARDs	2	44	Autologous	12
4	Snowden et al[27]	1999	Prospective study	Failed DMARDs	8	18-65	Autologous	18
5	Burt et al[25]	1999	Prospective study	Failed DMARDs	4	46.2	Autologous	12
6	Kim et al[35]	2002	Case report	Failed DMARDs	1	54	Autologous	6
7	Tyndall et al[29]	2001	Prospective study	Primary treatment	43	NR	Autologous	11
8	van Laar et al[28]	2001	Prospective study	Failed DMARDs	8	18-60	Autologous	18
9	Verburg et al[30]	2001	Prospective study	Failed DMARDs	14	43	Autologous	12
10	Bingham et al[11]	2001	Prospective study	Failed DMARDs	6	37.33	Autologous	20
11	Pavletic et al[31]	2001	Prospective study	Failed DMARDs	6	42.5	Autologous	26.5
12	Moore et al[13]	2001	RCT	Failed DMARDs	33	18-65	Autologous	12
13	Burt et al[36]	2004	Case report	Failed DMARDs	1	52	Allogenic	12
14	Snowden et al[15]	2004	Prospective study	Failed DMARDs	73	42	Autologous	18
15	Verburg et al[32]	2005	Prospective study	Failed DMARDs	8	35-55 years	Autologous	24
16	Teng et al[9]	2005	Prospective study	Failed DMARDs	8	43	Allogenic	60
17	Silva et al[12]	2018	Retrospective study	Failed DMARDs (10), failed autologous HSCT (1), secondary haemophagocytic lymphohistiocytosis (5)	16	12	Allogenic	29

DMARDs: Disease modifying anti-rheumatic drugs; HSCT: Haematopoietic stem cell transplant; NR: Not reported; RCT: Randomised controlled trial.