Copyright
©The Author(s) 2021.
World J Biol Chem. Sep 27, 2021; 12(5): 70-86
Published online Sep 27, 2021. doi: 10.4331/wjbc.v12.i5.70
Published online Sep 27, 2021. doi: 10.4331/wjbc.v12.i5.70
Figure 2 Downstream mammalian target of rapamycin complex 1 substrate S6 kinase beta-1 phosphorylation of insulin receptor sub strates 1 at Ser307 and Ser636/639 leads to insulin receptor substrates 1 degradation.
Blue arrows (→) indicate activation of the substrate, black arrow (→) indicates degradative pathway. Figure created with BioRender.com. S6K1: S6 kinase beta-1; IRS: Insulin receptor substrates.
- Citation: O'Reilly CL, Uranga S, Fluckey JD. Culprits or consequences: Understanding the metabolic dysregulation of muscle in diabetes. World J Biol Chem 2021; 12(5): 70-86
- URL: https://www.wjgnet.com/1949-8454/full/v12/i5/70.htm
- DOI: https://dx.doi.org/10.4331/wjbc.v12.i5.70