Culprits or consequences: Understanding the metabolic dysregulation of muscle in diabetes

doi:10.4331/wjbc.v12.i5.70

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Sep 27, 2021 (publication date) through Nov 25, 2024

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Sep 27, 2021; 12(5): 70-86
Published online Sep 27, 2021. doi: 10.4331/wjbc.v12.i5.70

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Figure 2 Downstream mammalian target of rapamycin complex 1 substrate S6 kinase beta-1 phosphorylation of insulin receptor substrates 1 at Ser307 and Ser636/639 leads to insulin receptor substrates 1 degradation. Blue arrows (→) indicate activation of the substrate, black arrow (→) indicates degradative pathway. Figure created with BioRender.com. S6K1: S6 kinase beta-1; IRS: Insulin receptor substrates.

Citation: O'Reilly CL, Uranga S, Fluckey JD. Culprits or consequences: Understanding the metabolic dysregulation of muscle in diabetes. World J Biol Chem 2021; 12(5): 70-86
URL: https://www.wjgnet.com/1949-8454/full/v12/i5/70.htm
DOI: https://dx.doi.org/10.4331/wjbc.v12.i5.70