Epigenetic basis of Alzheimer disease

Figure 4 Relevance of epigenetics in aging, neurodegeneration, and Alzheimer disease. Changes in the epigenomes are detected during aging, from young to older people, and in Alzheimer disease (AD) patients. The senescent cells are accumulated during aging. The expression of genes associated with neurodegeneration is increased, whereas the expression of genes associated with neuroprotection is decreased during aging. All these changes are increased in AD patients. A connection between these processes may be critical in aging and during the progression of AD.