Epigenetic basis of Alzheimer disease

Figure 3 Regulation of β-amyloid production pathway and its epigenetic alterations. The deregulation of some miRNAs and some epigenetic modifications increase the production, secretion, and accumulation of β-amyloid. Furthermore, some long non-coding RNAs (lncRNA), such as lncRNA-51A, lncRNA-BC1, lncRNA-17A and lncRNA-BACE-AS are involved in the overproduction of β-amyloid. Pink and blue arrows indicate an increase and decrease of expression, respectively. AD: Alzheimer disease; APP: β-amyloid precursor protein; lncRNA: Long non-coding RNAs; miRNA: MicroRNA.