Fasciculation and elongation zeta proteins 1 and 2: From structural flexibility to functional diversity

Table 1 Identities and similarities between human proteins FEZ1, FEZ2 and UNC-76 from C. elegans

	UNC-76 identity (%)	UNC-76 similarity (%)	FEZ1 identity (%)	FEZ1 similarity (%)
FEZ1	35	46	-	-
FEZ2	34	45	49	56

Alignment of 376 and 385 amino acid UNC-76, 251 amino acid FEZ2, and 392 amino acid FEZ1. It is noteworthy that the N-terminal region shows to be more divergent, but yet with substantial similarity. The C-terminal region presented three particular regions with more similarity (amino acids 179-197, 251-307, and 354-381 – numbered according to the C. elegans protein)[1]. FEZ: Fasciculation and elongation zeta/zygin; UNC: Uncoordinated.