Targeted therapies in epithelial ovarian cancer: Molecular mechanisms of action

doi:10.4331/wjbc.v1.i7.209

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Jul 26, 2010 (publication date) through Nov 16, 2024

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Jul 26, 2010; 1(7): 209-220
Published online Jul 26, 2010. doi: 10.4331/wjbc.v1.i7.209

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Figure 4 Effect of DNA repair systems on poly(ADP-ribose) polymerase activity. Double-strand breaks (DSBs) lead to the activation of poly(ADP-ribose) polymerases (PARPs). PARP plays a key role in the repair of SSBs. Treatment with a PARP inhibitor induces DSBs and selectively kills homologous recombination (HR)/breast and ovarian cancer susceptibility gene (BRCA)-deficient cells.

Citation: Itamochi H. Targeted therapies in epithelial ovarian cancer: Molecular mechanisms of action. World J Biol Chem 2010; 1(7): 209-220
URL: https://www.wjgnet.com/1949-8454/full/v1/i7/209.htm
DOI: https://dx.doi.org/10.4331/wjbc.v1.i7.209