Plasma membrane calcium ATPase proteins as novel regulators of signal transduction pathways

Figure 2 Physiological consequences of the interaction between PMCAs and signaling partner proteins in the cardiovascular system. The figure depicts regulatory interactions between PMCA and calcium-dependent signaling proteins in cardiovascular cells. These interactions play a pivotal role in the regulation of cardiovascular physiology via regulation of the NO and calcineurin/NFAT signal transduction pathways. CnA: Calcineurin A; sGC: Soluble guanylyl cyclase; PDE: Phosphodiesterase; PKA: Protein kinase A; PBL: Phospholamban; cTn I: Cardiac troponin I; βAR: β-adrenergic receptor; AC: Adenylyl cyclase; NFAT: Nuclear factor of activated T cells.