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Copyright ©2010 Baishideng Publishing Group Co.
World J Biol Chem. Jun 26, 2010; 1(6): 201-208
Published online Jun 26, 2010. doi: 10.4331/wjbc.v1.i6.201
Figure 1
Figure 1 Model of plasma membrane calcium ATPase (PMCA) as a regulator of signal transduction pathways. PMCA pumps calcium out of the cell and generates a microenvironment where the intracellular calcium concentrations are very low. Interaction with the intracellular domains of PMCA tethers partner proteins to this low-calcium microenvironment, which results in downregulation of the enzymatic activity of calcium/calmodulin-dependent proteins. Ca2+/CaM-dep, calcium/calmodulin-dependent enzyme.