Is tau a suitable therapeutical target in tauopathies?

Figure 2 Tau could have two opposite effects on axonal transport. A: It could facilitate the presence of acetylated microtubules and, therefore, the binding of kinesin to them. It would facilitate axonal transport; B: However, tau and kinesin may compete for the same binding site in microtubules. It could decrease axonal transport. Probably, an optimal amount of tau is needed for an optimal axonal transport. HDAC6: Histone deacetylase 6.