Nomogram model including LATS2 expression was constructed to predict the prognosis of advanced gastric cancer after surgery

Table 1 Clinical information, n (%)

Characteristics	All patients cases (%)/median (IQR)	Training group cases (%)/median (IQR)	Validation group cases (%)/median (IQR)	P value
Sex
Male	197 (80.41)	142 (83.04)	55 (74.32)	0.16
Female	48 (19.59)	29 (16.96)	19 (25.68)
Age
< 65	98 (40.00)	64 (37.43)	34 (45.95)	0.27
≥ 65	147 (60.00)	107 (62.57)	40 (54.05)
Hypertension
No	159 (64.90)	115 (67.25)	44 (59.46)	0.30
Yes	86 (35.10)	56 (32.75)	30 (40.54)
Diabetes
Yes	23 (9.39)	13 (7.60)	10 (13.51)	0.22
No	222 (90.61)	158 (92.40)	64 (86.49)
Chronic lung disease
Yes	9 (3.67)	6 (3.51)	3 (4.05)	1
No	236 (96.33)	165 (96.49)	71 (95.95)
Smoking
Yes	223 (91.02)	154 (90.06)	69 (93.24)	0.58
No	22 (8.98)	17 (9.94)	5 (6.76)
Lymphatic invasion
Yes	200 (81.63)	140 (81.87)	60 (81.08)	1
No	45 (18.37)	31 (18.13)	14 (18.92)
LATS2
High	164 (66.90)	121 (70.70)	43 (58.10)	0.60
Low	81 (33.10)	50 (29.30)	31 (41.80)
Alcohol consumption
Yes	135 (55.10)	93 (54.39)	42 (56.76)	0.84
No	110 (44.90)	78 (45.61)	32 (43.24)
Tumor size
> 5 cm	205 (83.67)	145 (84.80)	60 (81.08)	0.59
≤ 5 cm	40 (16.33)	26 (15.20)	14 (18.92)
T stage
2	45 (18.37)	26 (15.20)	19 (25.68)	0.11
3	23 (9.39)	15 (8.77)	8 (10.81)
4	177 (72.24)	130 (76.03)	47 (63.51)
N stage
0	74 (30.20)	54 (31.58)	20 (27.03)	0.62
1	45 (18.37)	28 (16.37)	17 (22.97)
2	51 (20.82)	35 (20.47)	16 (21.62)
3	75 (30.61)	54 (31.58)	21 (28.38)

IQR: Interquartile range.

Table 2 Unifactorial and multifactorial cox analysis

Characteristics	Univariate analysis				Multivariate analysis
	HR	95%CI	P value	HR		95%CI	P value
Sex
Male	Reference
Female	0.700	0.397-1.233	0.217
Age
< 65	Reference			Reference			0.199
≥ 65	6.632	4.026-10.926	< 0.001	1.780		0.739-4.286
Hypertension
No	1.202	0.800-1.812	0.378
Yes	Reference
Diabetes
Yes	1.256	0.608-2.594	0.537
No	Reference
Chronic lung disease
Yes	0.807	0.255-2.552	0.716
No	Reference
Smoking
Yes	0.900	0.604-1.312	0.605
No	Reference
Lymphatic invasion
Yes	13.121	7.840-21.959	< 0.001	3.251		1.519-6.960	0.002
No	Reference			Reference
LATS2
High	0.327	0.217-0.495	< 0.001	0.522		0.307-0.887	0.016
Low	Reference			Reference
Alcohol consumption
Yes	1.186	0.796-1.767	0.402
No	Reference
Tumor size
> 5 cm	Reference			Reference
≤ 5 cm	319.955	42.319-2419.010	< 0.001	79.564		8.657-731.251	< 0.001
T stage
2	Reference
3	6.691	2.407-18.598	< 0.001	9.620		3.390-27.300	< 0.001
4	5.452	2.372-12.536	< 0.001	4.156		1.753-9.850	< 0.001
N stage
0	Reference
1	1.650	0.824-3.304	0.158	1.762		0.872-3.563	0.115
2	2.237	1.186-4.220	0.013	2.248		1.155-4.376	0.017
3	4.332	2.452-7.653	< 0.001	3.874		2.127-7.056	< 0.001

HR: Hazard ratio.

Table 3 Model consistency index (c-index)

Variables		Training group		Validation group
		C-index	95%CI	C-index	95%CI
Overall survival	TN stage	0.702	0.653-0.751	0.756	0.682-0.830
	TN stage + LATS2	0.785	0.742-0.828	0.830	0.761-0.899
	Nomogram	0.829	0.788-0.870	0.862	0.805-0.919