Cai RS, Yang WZ, Cui GR. Associate factors for endoscopic submucosal dissection operation time and postoperative delayed hemorrhage of early gastric cancer. World J Gastrointest Surg 2023; 15(1): 94-104 [PMID: 36741071 DOI: 10.4240/wjgs.v15.i1.94]
Corresponding Author of This Article
Ren-Song Cai, BSc, MD, Attending Doctor, Digestive Endoscopy Department, the Second Affiliated Hospital of Hainan Medical University, No. 368 Yehai Avenue, Longhua District, Haikou 570311, Hainan Province, China. cairensong@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
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World J Gastrointest Surg. Jan 27, 2023; 15(1): 94-104 Published online Jan 27, 2023. doi: 10.4240/wjgs.v15.i1.94
Table 1 Single-factor analysis of endoscopic submucosal dissection operation time
Factors
n
Operation time (min) (mean ± SD)
r/t/F
P value
Age (yr)
520
66.78 ± 40.89
0. 191
0.812
Sex
0.311
0.764
Male
367
64.19 ± 41.21
Female
153
73.38 ± 35.82
Underlying diseases
0.921
0.146
None
379
63.11 ± 27.17
Hypertension
126
70.91 ± 32.19
Diabetes
12
67.24 ± 41.65
Cirrhosis
3
78.55 ± 30.52
History of taking anticoagulant or antiplatelet drugs
1.260
0.262
Yes
31
59.51 ± 48.44
No
489
66.12 ± 20.38
Lesion location
1.333
0.198
Upper gastric body
112
75.76 ± 31.76
Middle gastric body
70
63.36 ± 38.91
Lower gastric body
338
65.54 ± 39.18
Maximum diameter of lesion
8.691
< 0.001
< 3.00 cm
351
52.22 ± 29.81
≥ 3.00 cm
169
90.38 ± 40.21
Lesion form
11.123
< 0.001
Uplift type
134
48.54 ± 28.11
Flat type
138
53.66 ± 31.81
Concave type
91
71.17 ± 33.71
Mixed type
157
109.33 ± 40.28
Combined ulcer or scar
7.288
0.001
Yes
64
93.17 ± 37.34
No
456
62.36 ± 31.97
Combined perforation
9.327
< 0.001
Yes
21
121.33 ± 41.19
No
499
63.17 ± 36.85
Infiltrative depth
5.442
0.017
Mucosa
397
55.44 ± 36.18
Submucosa
123
87.23 ± 39.67
Table 2 Indigenous test results of multivariate linear regression independent variables
Factors
Unstandardized β value
Sx value
Standardized β value
t value
P value
Intercept
21.674
0.433
-
36.188
< 0.001
Maximum diameter of lesion
8.815
0.684
0.732
3.812
< 0.001
Lesion form - flat
1.277
1.475
0.032
0.333
0.493
Lesion form - concave type
3.766
0.872
0.383
4.456
< 0.001
Lesion form - mixed
10.247
0.929
0.633
9.580
< 0.001
Combined ulcer or scar
4.417
0.305
0.180
3.154
0.007
Combined perforation
3.692
2.303
0.153
2.340
0.020
Infiltrative depth - submucosa
2.536
0.569
0.077
2.652
0.008
Table 3 Single-factor analysis of the bleeding group and non-bleeding group
Factors
Bleeding group (n = 43)
Non-bleeding (n = 477)
χ2 value
P value
Age (yr)
0.120
0.729
< 60
23
242
≥ 60
20
235
Sex
0.015
0.903
Male
30
337
Female
13
140
Underlying diseases
Hypertension
16
110
4.301
0.038
Diabetes
2
10
1.142
0.285
Cirrhosis
0
3
-
-
History of taking anticoagulant or antiplatelet drugs
59.148
< 0.001
Yes
14
17
No
29
460
Lesion location
0.489
0.783
Upper gastric body
10
102
Middle gastric body
7
63
Lower gastric body
26
312
Maximum diameter of lesion
29.677
< 0.001
< 3.00 cm
13
338
≥ 3.00 cm
30
139
Lesion form
11.098
0.011
Uplift type
7
127
Flat type
12
126
Concave type
15
76
Mixed type
9
148
Combined ulcer or scar
0.020
0.887
Yes
5
59
No
38
418
Combined perforation
1.044
0.307
Yes
3
18
No
40
459
Infiltrative depth
3.274
0.070
Mucosa
28
369
Submucosa
15
108
ESD operation time
6.979
0.008
< 60 min
16
277
≥ 60 min
27
200
Table 4 Logistic regression analysis of delayed hemorrhage after endoscopic submucosal dissection
Factors
β
Sx
Wald value
OR (95%CI)
P value
Hypertension
No
1
Yes
0.776
0.522
2.175
2.137 (0.912-2.643)
0.136
Taking anticoagulants
No
Yes
1.841
1.062
2.851
4.377 (0.657-37.912)
0.078
Maximum diameter of lesion
< 3.00 cm
1
≥ 3.00 cm
0.941
0.347
7.399
3.785 (1.165-4.277)
0.011
Lesion form
Uplift type
1
Flat type
0.701
1.031
0.452
2.011 (0.251-15.664)
0.072
Concave type
2.378
1.679
4.917
10.585 (2.133-35.381)
0.007
Mixed type
1.327
1.720
0.873
2.816 (0.463-19.832)
0.254
ESD operation time
< 60 min
1
≥ 60 min
1.446
1.271
3.541
2.958 (1.117-3.526)
0.011
Citation: Cai RS, Yang WZ, Cui GR. Associate factors for endoscopic submucosal dissection operation time and postoperative delayed hemorrhage of early gastric cancer. World J Gastrointest Surg 2023; 15(1): 94-104