Clinicopathological features and surgical outcome of patients with fibrolamellar hepatocellular carcinoma (experience with 22 patients over a 15-year period)

Table 4 Published series on fibrolamellar hepatocellular carcinoma

Ref.	n	Age	Male:female	Cirrhosis/ hepatitis	AFP elevated	Median size (cm)	> 1 tumor	Positive node	Vascular invasion	Initial operation	Repeat operation	Median f/u	5 yr survival	Prognostic factor
Hemming et al[18], 1997	10	31	50:50	NR	10%	8	20%	20%	NR	Phx 100%	50%	101	70%	NR
El-Gazzaz et al[19], 2000	20	27	65:35	0% hep B	0%	14	20%	30%	55%	Phx 55% OLT 45%	NR	25	50%	NONE
Kakar et al[20], 2005	20	27	53:27	0%	3/13 (23%)	< 10 31% ≥ 10 69%	10%	35%	NR	Phx 100%	NR	NR	62%	Metastasis at presentation
Stipa et al[21], 2006	28	28	43:57	0%	7%	9	11%	50%	36%	Phx 100%	61%	34	76%	Positive LN
Present study	22	29	50:50	9%/hepc	9%	12	13%	18%	23%	Phx 100%	18%	42	65%	Vascular invasiom

Hep: Hepatitis; AFP: Alpha-fetoprotein elevated (> 200 ng/mL); Phx: Partial hepatectomy; NR: Not reported; f/u: Follow up.