Restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis: A narrative review

Table 3 Studies comparing the mortality and morbidity of 2-stage and 3-stage restorative proctocolectomy with ileal pouch-anal anastomosis

Ref.	Type of study	Number of patients 2- vs 3-stage	Mortality (%)	Post-operative complications (%)	Sepsis/ septic shock (%)	Pouch leak (%)	Wound infection (%)	Intra-abdominal abscess (%)	Bowel obstruction (%)	Pouch failure (%)
2Nicholls et al[27]	Retrospective	2-stage: 57 3-stage: 95	2-stage: 2 3-stage: 0	2-stage: 49 3-stage: 51	2-stage: 20 3-stage: 17	2-stage: 10.3 3-stage: 3.6	2-stage: 9 3-stage: 12	2-stage: 2 3-stage: 1	2-stage: 9 3-stage: 15	2-stage: 2a 3-stage: 9a
Pandey et al[28]	Retrospective	2-stage: 68 3-stage: 50	2-stage: 1.47 3-stage: 0	2-stage: 55.2% 3-stage: 52.2%	Unknown	2-stage: 13.2 3-stage: 8	2-stage: 8.8 3-stage: 7	2-stage: 16.2 3-stage: 6	2-stage: 11.8 3-stage: 9	Unknown
Hicks et al[29]	Retrospective	2-stage: 116 3-stage: 28	2-stage: 0 3-stage: 0	Mean number of complications: 1.18 vs 1.29	Unknown	2-stage: 10.3 3-stage: 3.6	Unknown	2-stage: 21.6 3-stage: 21.4	2-stage: 20.8 3-stage: 3.6c	2-stage: 6.7 3-stage: 3.6
Bikhchandani et al[30]	Retrospective	2-stage: 1452 3-stage: 550	2-stage: 0.4 3-stage: 0	2-stage: 11.5% 3-stage: 9.4%	2-stage: 9.1 3-stage: 7.4	2-stage: 9.4 3-stage: 6.71	2-stage: 10.5 3-stage: 13.11	Unknown	Unknown	Unknown

Differences are not significantly different.

¹Reported as deep organ space infection;

²Studies including patients affected by ulcerative colitis and familial adenomatous polyposis;

^aP < 0.05;

^cP = 0.03.