Critical appraisal of laparoscopic vs open rectal cancer surgery

Table 6 Summary of studies reporting at least 5 year survival outcomes of laparoscopic vs open rectal resection

Ref.	Type of study	No. of patients with rectal cancer	5 yr overall survival	Remarks
Lujan et al[4]	Randomized Controlled Trial	204 (103 open, 101 lap)	75.3% (open) vs 72.1% (lap) P = 0.980	Middle and low rectal cancers only
Green et al[26], (MRC CLASICC trial)	Randomized Controlled Trial	381 (128 open, 253 lap)	52.9% (open) vs 60.3% (lap) P = 0.132
Ng et al[29]	Pooled Analysis of 3 RCT	278 (142 open, 136 lap)	61.1% (open) vs 63.0% (lap) P = 0.505	10 yr overall survival
Laurent et al[6]	Retrospective Comparative Study	471 (233 open, 239 lap)	79% (open) vs 82% (lap) P = 0.52	Cancer free survival main outcome measure
Day et al[25]	Retrospective	222 (133 open, 89 lap)	58% (open) vs 75% (lap) P = 0.014	Laparoscopic group had better survival on multivariate analysis as well
Baik et al[24]	Case-matched Controlled Analysis	162 (108 open, 54 lap)	88.5% (open) vs 90.8% (lap) P = 0.261
Li et al[28]	Retrospective	238 (123 open, 113 lap)	78.9% (open) vs 77.9% (lap) P = 0.913	Middle and low rectal cancers only
Lim et al[21]	Retrospective	191 (91 open, 100 lap)	72.6% (open) vs 74.7% (lap) P = 0.54
Zhong et al[30]	Retrospective	514 (238 open, 186 lap)	61.3% (open) vs 69.4% (lap) P = 0.067
Agha et al[23]	Retrospective	225 (all laparoscopic)	50.5% (lap)	10 yr overall survival