NOD2 mutations and colorectal cancer - Where do we stand?

Table 1 Genotype frequencies of the nucleotide-binding and oligomerization-domain containing 2 polymorphisms

	Country	Finland[36]	Greece[40]	Hungary[39]	New Zealand[43]	Portugal[38]
	CRC (n)	953/960/9261	104	194	133	112
	Controls (n)	508/508/3481	100	200	201	152
R702W
CRC	% Allele frequency	2.2	4.8	1.8	7.1	12.5
Control	% Allele frequency	2.1	1.0	1.5	3.0	5.3
	P value	0.88	0.02	0.78	0.03	0.03
G908R
CRC	% Allele frequency	0.3	8.65	1.8	2.2	2.73
Control	% Allele frequency	0.2	3.5	1.8	0.8	3.29
	P value	0.57	0.025	0.95	0.09	0.77
3020insC
CRC	% Allele frequency	1.9	12.5	3.6	2.2	0.89
Control	% Allele frequency	1.9	6	2.5	1.0	1.3
	P value	0.96	0.017	0.40	0.19	0.75
At least one mutation
CRC	% Genotype frequency	-	51.9	14.4	21.8	16.1
Control	% Genotype frequency	-	21.0	11.5	8.9	9.9
	P value	-	< 0.0001	0.45	0.001	0.132

¹CRC cases and controls for each mutation, respectively (R702W, G908R, 3020insC). CRC: Colorectal cancer.