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Copyright ©The Author(s) 2016.
World J Gastrointest Surg. Oct 27, 2016; 8(10): 660-669
Published online Oct 27, 2016. doi: 10.4240/wjgs.v8.i10.660
Table 1 Immunomarkers and mutations for appendiceal goblet cell carcinoids, typical neuroendocrine tumors and adenocarcinoma
MarkersGoblet cell carcinoidTypical carcinoidAdenocarcinoma
CEA+-+
CK7+-+
CK20+-+
CDX2+-+
CD56+/-++-
CAM5.2+-+
Synaptophysin+/-++-
Chromogranin A+/-++-
Β-Catenin (nuclear)--+
p53+/--++
Ki67%+/-+/-++
MUC1--++
MUC2++-+/-
E-cadherin expressionNNU
MATH-1 expression++-
KRAS mutation--+
SMAD4 mutation--+
Notch signaling inhibitionU+-
MMR (MSH2, MSH6, MLH1, PMS2)--+/-