Sentinel node navigation surgery for gastric cancer: Overview and perspective

Table 2 Cinical trials that served to focus on the limitation of sentinel lymph node surgery for gastric cancer in a current decade

Ref.	Year	n	Detection rate (%)	Sensitivity (%)	Main results
Miyashiro et al[40]	2014	440	97.80	46% of false negative rate	The proportion of false negatives was 46% (13/28) after a learning period. False negatives remained at 14% (4/28) even by examining additional sections of GNs by paraffin section
Ryu et al[41]	2011	2684	87.80	97.50	A meta-analysis of feasibility studies showed SNB in gastric cancer may not be clinically applicable due to the unsatisfactory sensitivity and heterogeneity among practicing surgeons
Wang et al[11]	2011	2128	93.70	76.90	The reliability of SNLB in EGC is currently not comparable to SNLB in breast cancer or melanoma
Becher et al[8]	2009	27	100.00	83.00	The negative predictive value is 75% and clinical use of SN mapping for gastric cancer was not recommended
Yanagita et al[56]	2008	133	98.50	100.00	Micrometastasis and ITCs should be removed, especially during SN navigation surgery
Tonouchi et al[65]	2005	37	94.60	75.00	During laparoscopic SN mapping there is a high risk of false negativity with SNs located in the right pericardial region

GN: Green node; EGC: Early gastric cancer; ITCs: Isolated tumor cells; SNB: Sentinel node biopsy; SNLB: Sentinel lymph node biopsy; ITCs: Isolated tumor cells.