Impact of medical and surgical intervention on survival in patients with cholangiocarcinoma

Table 3 Characteristics of surgical groups n (%)

	Surgery alone (n = 69)	Adjuvant chemotherapy (n = 20)	Adjuvant chemoradiation (n = 21)	P value
Age group (yr)				< 0.0001
18-49	13 (18.8)	6 (30.0)	10 (47.6)
50-64	29 (42.0)	6 (30.0)	7 (33.3)
65-79	25 (36.2)	8 (40.0)	4 (19.0)
≥ 80	2 (2.9)	0 (0.0)	0 (0.0)
Sex				0.018
Men	41 (59.4)	13 (65.0)	14 (66.7)
Women	28 (40.6)	7 (35.0)	7 (33.3)
Race				0.497
Non-hispanic white	33 (47.8)	11 (55.0)	9 (42.9)
Black	2 (2.9)	0 (0.0)	2 (9.5)
Hispanic white	20 (29)	3 (15.0)	5 (23.8)
Other	14 (20.3)	6 (30.0)	5 (23.8)
Socioeconomic status				0.603
Highest	18 (26.1)	7 (35.0)	7 (33.3)
Middle	41 (59.4)	9 (45.0)	12 (57.1)
Lowest	10 (14.5)	4 (20.0)	2 (9.5)
Tumor				0.000
Liver	17 (24.6)	3 (15.0)	2 (9.5)
Location
Bile duct	52 (75.4)	17 (85.0)	19 (90.5)
Grade				0.684
Well differentiated	13 (23.6)	3 (20.0)	3 (16.7)
Moderately differentiated	21 (38.2)	4 (26.7)	6 (33.3)
Poorly differentiated	21 (38.1)	8 (53.3)	9 (50.0)
Tumor size (cm)				0.825
≤ 5	24 (54.5)	3 (25.0)	6 (60.0)
> 5	20 (45.5)	9 (75.0)	4 (40.0)
Summary				0.016
Local	23 (38.3)	3 (20.0)	7 (38.9)
Stage
Regional	24 (40.0)	5 (33.3)	6 (33.3)
Distant	13 (21.7)	7 (46.7)	5 (27.8)
T stage				0.071
T1	24 (40.0)	5 (29.4)	7 (36.8)
T2	9 (15.0)	3 (17.6)	2 (10.5)
T3	12 (20.0)	3 (17.6)	3 (15.8)
T4	15 (25.0)	6 (35.3)	7 (36.8)
N stage				0.396
N0	44 (83.0)	10 (62.5)	14 (82.4)
N1	9 (17.0)	6 (37.5)	3 (17.6)
AJCC7 stage				< 0.0001
I	22 (40.0)	5 (29.4)	6 (33.3)
II	7 (12.7)	1 (5.9)	1 (5.6)
III	13 (23.6)	3 (17.7)	5 (27.8)
IV	13 (23.7)	8 (47.0)	6 (33.4)

Characteristics found to be significantly different between surgical patients were age, gender, tumor location, and stage. Patients in the adjuvant chemoradiation group were male and much younger in age compared to the other groups. AJCC: American Joint Committee on Cancer.