Impact of medical and surgical intervention on survival in patients with cholangiocarcinoma

Table 2 Characteristics of patient and treatment groups n (%)

	Chemo only (n = 153 )	Chemoradiation (n = 61)	Surgery (n = 114 )	P value
Age group (yr)				< 0.0001
18-49	29 (19.0)	10 (16.4)	29 (25.4)
50-64	62 (40.5)	20 (32.8)	44 (38.6)
65-79	55 (35.9)	31 (50.8)	39 (34.2)
≥ 80	7 (4.6)	0 (0.0)	2 (1.8)
Sex				0.000
Men	57 (37.3)	36 (59.0)	69 (60.5)
Women	96 (62.7)	25 (41.0)	45 (39.5)
Race				0.002
Non-hispanic white	74 (48.4)	26 (42.6)	53 (46.5)
Black	9 (5.9)	7 (11.5)	4 (3.5)
Hispanic white	37 (24.2)	8 (13.1)	29 (25.4)
Other	33 (21.6)	20 (32.8)	28 (24.6)
Socioeconomic status				0.046
Highest	38 (24.8)	18 (29.5)	33 (28.9)
Middle	96 (62.7)	35 (57.4)	65 (57.0)
Lowest	19 (12.4)	8 (13.1)	16 (14.0)
Tumor				0.000
Liver	21 (13.7)	3 (4.9)	22 (19.3)
Location
Bile duct	132 (86.3)	58 (95.1)	92 (80.7)
Grade				0.685
Well differentiated	12 (19.4)	4 (17.4)	19 (21.1)
Moderately differentiated	20 (32.3)	5 (21.7)	33 (36.7)
Poorly differentiated	30 (48.4)	14 (60.9)	38 (42.2)
Tumor size (cm)				0.060
≤ 5	10 (27.8)	7 (58.3)	34 (50.0)
> 5	26 (72.2)	5 (41.7)	34 (50.0)
Summary				0.000
Local	17 (15.3)	9 (21.4)	35 (36.1)
Stage
Regional	29 (26.1)	16 (38.1)	36 (37.1)
T stage				0.001
T1	23 (24.5)	8 (19.5)	37 (37.4)
T2	2 (2.1)	3 (7.3)	14 (14.1)
T3	19 (20.2)	10 (24.4)	18 (18.2)
T4	50 (53.2)	20 (48.8)	30 (30.3)
N stage				0.211
N0	53 (72.6)	22 (68.8)	71 (79.8)
N1	20 (27.4)	10 (31.3)	18 (20.2)
M stage				< 0.0001
M0	60 (46.9)	32 (68.1)	96 (87.3)
M1	68 (53.1)	15 (31.9)	14 (12.7)
AJCC7 stage				< 0.0001
I	13 (14.4)	2 (6.3)	34 (36.6)
II	1 (1.1)	2 (6.3)	9 (9.7)
III	18 (11.8)	7 (11.5)	23 (20.2)
IV	58 (64.4)	21 (65.6)	27 (29.1)
Chemotherapy	153 (100.0)	61 (100.0)	41 (36.0)	< 0.0001
Radiation	0 (0.0)	61 (100.0)	25 (21.9)	< 0.0001

In general, characteristics that were different between the surgical patients and the non-surgical patients were age, gender, tumor location, and stage. Patients in the surgery cohort were more often male, white, and young. chemo: Chemotherapy; AJCC: American Joint Committee on Cancer.