Lymph node harvest in colon and rectal cancer: Current considerations

Table 4 Survival by lymph node ratio in stage III colorectal cancer

Authors	Study/country	Tumor location	No. of patients	Lower cut off LNR	5-year survival %	Significance
Observational study
Lee et al[68]	South Korea	Colon	201	0.01-0.11	83.64	P < 0.0001
				0.12-0.24	61.14
				0.25-0.92	204
Schumacher et al[69]	United States	Colon	75	< 0.18	8541	P < 0.005
				≥ 0.18	5041
Peschaud et al[73]	France	Rectum	307	0.01-0.07	794; 9232	P = 0.0064
				> 0.2	424; 6632	P = 0.00033
Park et al[71]	South Korea	Colon	318	< 0.059	83.642	P = 0.002
				0.059-0.23	71.142
				> 0.23	5542
Rosenberg et al[74]	Germany	Colorectal	3026	0.01-0.17	60.63	P < 0.001
				0.18-0.41	34.43
				0.42-0.69	17.63
				> 0.70	5.33
Multicenter observational study
De Ridder et al[67]	SEER cancer registry (Belgium)	Colon	26 181	≤ 0.4	565	P < 0.0001
				≥ 0.4	255
Wang et al[70]	SEER cancer registry (United States)	Colon (stage IIIB)	14 644	< 1/14	63.53	P < 0.0001
				1/14-0.25	54.73
				0.25-0.50	44.43
				0.50-1.0	34.23
	SEER cancer registry (United States)	Colon (stage IIIC)	7658	< 1/14	Not estimated	P < 0.0001
				1/14-0.25	49.63
				0.25-0.50	41.73
				0.50-1.0	25.23
Rosenberg et al[75]	Munich Cancer Registry (MCR, Germany)	Colorectal	27 803	0	71.43	P < 0.001
				0.01-0.17	52.43
				0.18-0.41	33.33
				0.42-0.69	19.83
				> 0.70	8.33

¹Approximate figures taken from graph in report. Exact 5-yar survival by lymph node ratio (LNR) not stated in report;

²3-year survival, Surveillance, Epidemiology, and End Results (SEER);

³Overall survival;

⁴Disease free survival;

⁵Cause specific survival.