Review
Copyright ©2010 Baishideng.
World J Gastrointest Surg. Mar 27, 2010; 2(3): 70-77
Published online Mar 27, 2010. doi: 10.4240/wjgs.v2.i3.70
Table 1 Lymph node ratio (LNR) in colorectal cancer
Author, year[Reference]No. of patientsSelection of patientsCut-off of LNR5-year overall survival (%)Uni P valueMulti P valueHR (95% CI)
Berger et al, 2005[22]3411Stage II and III< 0.0579< 0.00011NSa-
colon cancer0.05-0.19731< 0.0001b13.87 (NA)b
0.2-0.39631< 0.0001c112.43 (NA)c
0.4-1.052
De Ridder et al, 2006[48]26181Node-positive-0.456-< 0.0001-
colon cancer0.4-25
Schumacher et al, 2007[50]232Non-stage IV< 0.08-< 0.05--
colon cancer0.08 ≤-
Lee et al, 2007[51]201Stage III colon cancer0.01-0.1183.6d< 0.0001< 0.00011
0.12-0.2461.1d2.973 (1.407-6.280)
0.25-0.9220d8.362 (3.739-18.704)
Wang et al, 2008, 2009[27,54]24477Stage III colon cancer< 1/1464.8< 0.00011< 0.000112.30 (2.083-2.545)
1/14 ≤ - < 0.2556.2
0.25 ≤ - 0.5045.1
0.50 ≤ - ≤ 1.029.6
Rosenberg et al, 2008[26]3026Colorectal cancer087.1< 0.001< 0.0011 (NA)
0.01-0.1760.61.92 (NA)
0.18-0.4134.42.92 (NA)
0.42-0.6917.63.62 (NA)
0.70 ≤5.34.31 (NA)
Peng et al, 2008[52]318Node-positive< 0.1472.190.00210.00313.11 (1.47-6.58)
rectal cancer0.14-0.4961.92
0.5-138.47
Peschaud et al, 2008[53]307Rectal cancer089e0.001310.000311.019 (1.009-1.029)
0.01-0.0792e
0.07-0.271e
0.2 <67e
Derwinger et al, 2008[55]136Stage IV0-0.15708 df< 0.00491< 0.05g2.1 (1.3-3.6)g
colorectal cancer0.16-0.65438 df
0.66-1277 df
Derwinger et al, 2008[56]265Stage III colon cancer0-0.12580h< 0.0011< 0.0002110.6 (3.2-31.8)
0.126-0.266-
0.267-0.450-
0.451-129h
Vather et al, 2009[57]2364Stage III colon cancerLowest group55-60< 0.0001--
Higher group10-20
Chin et al, 2009[34]490Stage III colon cancer ≤ 0.466.7d< 0.00011
(LN ≥ 12)0.4 < ≤ 0.735.1d0.0012.298 (1.384-3.815)
0.7 <0d< 0.0017.407 (3.153-17.397)
Vaccaro et al, 2009[61]362Stage III colon cancer< 0.2564.9< 0.00010.0051
0.25 ≤38.32.3 (1.3-4.1)
Park et al, 2009[28]318Stage III colon cancer< 0.05983.6h0.0002--
0.059-0.2371.1h
0.23 <55h
Priolli et al, 2009[58]113Colorectal cancer0More than 800.0310.00318.575 (NA)
0.01-0.267.6
0.21 ≤37.5
Moug et al, 2009[59]295Colorectal cancer< 0.05-< 0.0011< 0.001i111.65 (5.00-27.15)i
0.05-0.19-1< 0.001j113.40 (3.64-49.10)j
0.20-0.39-
0.40-1.00-
Kim et al, 2009[60]232Stage III rectal cancer ≤ 0.189< 0.0011
0.1 < - ≤ 0.2670.6231.260 (0.501-3.173)
0.2 < - ≤ 0.4640.00472.435 (1.012-5.862)
0. 4 <500.0053.701 (1.493-9.178)