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World J Gastrointest Surg. Mar 27, 2010; 2(3): 70-77
Published online Mar 27, 2010. doi: 10.4240/wjgs.v2.i3.70
Published online Mar 27, 2010. doi: 10.4240/wjgs.v2.i3.70
Author, year | [Reference] | No. of patients | Selection of patients | Cut-off of LNR | 5-year overall survival (%) | Uni P value | Multi P value | HR (95% CI) |
Berger et al, 2005 | [22] | 3411 | Stage II and III | < 0.05 | 79 | < 0.0001 | 1NSa | - |
colon cancer | 0.05-0.19 | 73 | 1< 0.0001b | 13.87 (NA)b | ||||
0.2-0.39 | 63 | 1< 0.0001c | 112.43 (NA)c | |||||
0.4-1.0 | 52 | |||||||
De Ridder et al, 2006 | [48] | 26181 | Node-positive | -0.4 | 56 | - | < 0.0001 | - |
colon cancer | 0.4- | 25 | ||||||
Schumacher et al, 2007 | [50] | 232 | Non-stage IV | < 0.08 | - | < 0.05 | - | - |
colon cancer | 0.08 ≤ | - | ||||||
Lee et al, 2007 | [51] | 201 | Stage III colon cancer | 0.01-0.11 | 83.6d | < 0.0001 | < 0.0001 | 1 |
0.12-0.24 | 61.1d | 2.973 (1.407-6.280) | ||||||
0.25-0.92 | 20d | 8.362 (3.739-18.704) | ||||||
Wang et al, 2008, 2009 | [27,54] | 24477 | Stage III colon cancer | < 1/14 | 64.8 | < 0.0001 | 1< 0.0001 | 12.30 (2.083-2.545) |
1/14 ≤ - < 0.25 | 56.2 | |||||||
0.25 ≤ - 0.50 | 45.1 | |||||||
0.50 ≤ - ≤ 1.0 | 29.6 | |||||||
Rosenberg et al, 2008 | [26] | 3026 | Colorectal cancer | 0 | 87.1 | < 0.001 | < 0.001 | 1 (NA) |
0.01-0.17 | 60.6 | 1.92 (NA) | ||||||
0.18-0.41 | 34.4 | 2.92 (NA) | ||||||
0.42-0.69 | 17.6 | 3.62 (NA) | ||||||
0.70 ≤ | 5.3 | 4.31 (NA) | ||||||
Peng et al, 2008 | [52] | 318 | Node-positive | < 0.14 | 72.19 | 0.002 | 10.003 | 13.11 (1.47-6.58) |
rectal cancer | 0.14-0.49 | 61.92 | ||||||
0.5-1 | 38.47 | |||||||
Peschaud et al, 2008 | [53] | 307 | Rectal cancer | 0 | 89e | 0.0013 | 10.0003 | 11.019 (1.009-1.029) |
0.01-0.07 | 92e | |||||||
0.07-0.2 | 71e | |||||||
0.2 < | 67e | |||||||
Derwinger et al, 2008 | [55] | 136 | Stage IV | 0-0.15 | 708 df | < 0.0049 | 1< 0.05g | 2.1 (1.3-3.6)g |
colorectal cancer | 0.16-0.65 | 438 df | ||||||
0.66-1 | 277 df | |||||||
Derwinger et al, 2008 | [56] | 265 | Stage III colon cancer | 0-0.125 | 80h | < 0.001 | 1< 0.0002 | 110.6 (3.2-31.8) |
0.126-0.266 | - | |||||||
0.267-0.450 | - | |||||||
0.451-1 | 29h | |||||||
Vather et al, 2009 | [57] | 2364 | Stage III colon cancer | Lowest group | 55-60 | < 0.0001 | - | - |
Higher group | 10-20 | |||||||
Chin et al, 2009 | [34] | 490 | Stage III colon cancer | ≤ 0.4 | 66.7d | < 0.0001 | 1 | |
(LN ≥ 12) | 0.4 < ≤ 0.7 | 35.1d | 0.001 | 2.298 (1.384-3.815) | ||||
0.7 < | 0d | < 0.001 | 7.407 (3.153-17.397) | |||||
Vaccaro et al, 2009 | [61] | 362 | Stage III colon cancer | < 0.25 | 64.9 | < 0.0001 | 0.005 | 1 |
0.25 ≤ | 38.3 | 2.3 (1.3-4.1) | ||||||
Park et al, 2009 | [28] | 318 | Stage III colon cancer | < 0.059 | 83.6h | 0.0002 | - | - |
0.059-0.23 | 71.1h | |||||||
0.23 < | 55h | |||||||
Priolli et al, 2009 | [58] | 113 | Colorectal cancer | 0 | More than 80 | 0.03 | 10.003 | 18.575 (NA) |
0.01-0.2 | 67.6 | |||||||
0.21 ≤ | 37.5 | |||||||
Moug et al, 2009 | [59] | 295 | Colorectal cancer | < 0.05 | - | < 0.001 | 1< 0.001i | 111.65 (5.00-27.15)i |
0.05-0.19 | - | 1< 0.001j | 113.40 (3.64-49.10)j | |||||
0.20-0.39 | - | |||||||
0.40-1.00 | - | |||||||
Kim et al, 2009 | [60] | 232 | Stage III rectal cancer | ≤ 0.1 | 89 | < 0.001 | 1 | |
0.1 < - ≤ 0.2 | 67 | 0.623 | 1.260 (0.501-3.173) | |||||
0.2 < - ≤ 0.4 | 64 | 0.0047 | 2.435 (1.012-5.862) | |||||
0. 4 < | 50 | 0.005 | 3.701 (1.493-9.178) |
- Citation: Noura S, Ohue M, Kano S, Shingai T, Yamada T, Miyashiro I, Ohigashi H, Yano M, Ishikawa O. Impact of metastatic lymph node ratio in node-positive colorectal cancer. World J Gastrointest Surg 2010; 2(3): 70-77
- URL: https://www.wjgnet.com/1948-9366/full/v2/i3/70.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v2.i3.70