Novel multimodal analgesic regimen for perioperative pain management after hepatic artery infusion chemotherapy in patients with advanced hepatocellular carcinoma

Table 2 Compared two groups of visual analog scale pain score

	Time point	Control group (n = 50)	Multimodal group (n = 50)	t	P value
Rest	1 hour before HAIC	0.58 ± 0.57	0.54 ± 0.54	0.358	0.721
	During the HAIC	0.38 ± 0.49	0.46 ± 0.54	0.775	0.440
	T0	1.5 ± 0.58	0.56 ± 0.50	8.667	0.001
	T2	1.8 ± 0.73	1.14 ± 0.57	5.040	0.006
	T4	1.88 ± 0.77	0.96 ± 0.53	6.928	0.001
	T6	1.78 ± 0.51	0.98 ± 0.68	6.640	0.001
	T12	1.62 ± 0.49	0.7 ± 0.54	8.883	0.001
	T24	0.56 ± 0.58	0.34 ± 0.56	1.939	0.055
	T48	0.52 ± 0.58	0.36 ± 0.48	1.497	0.138
Movement	1 hour before HAIC	0.7 ± 0.54	0.62 ± 0.53	0.745	0.458
	During the HAIC	0.5 ± 0.51	0.62 ± 0.60	-1.079	0.283
	T0	1.68 ± 0.51	0.8 ± 0.49	8.733	0.001
	T2	1.9 ± 0.89	1.44 ± 0.54	3.133	0.002
	T4	1.94 ± 0.77	1.58 ± 0.50	6.928	0.001
	T6	1.96 ± 0.45	0.96 ± 0.53	6.640	0.001
	T12	1.64 ± 0.69	0.74 ± 0.53	7.310	0.001
	T24	0.84 ± 0.47	0.82 ± 0.72	0.165	0.869
	T48	0.52 ± 0.58	0.46 ± 0.61	0.503	0.616

HAIC: Hepatic artery infusion chemotherapy.