Optimal timing of endoscopic biliary drainage for bile duct leaks: A multicenter, retrospective, clinical study

Table 4 Univariable and multivariable analysis of variables associated with biliary stricture, n (%)

Variable	Univariable analysis				Multivariable analysis
	Biliary stricture (n = 29)	No biliary stricture (n = 65)	P value	OR		95%CI	P value
Basic demographics
Sex, female	12 (41.4)	16 (24.6)	0.104	-		-	-
Age, years, mean ± SD	54.14 ± 13.3	50.6 ± 12.39	0.585	-		-	-
BMI, mean ± SD	23.1 ± 3.2	23.1 ± 3.7	0.316	-		-	-
CCI, (Q1, Q3)	2 (1, 4)	3 (1, 5)	0.021	1.109		0.918-1.338	0.217
Laboratory test within 3 days before ERCP
WBC, × 109/L (Q1, Q3)	8.4 (3, 4)	10.0 (4, 8)	0.110	-		-	-
ALT, U/L (Q1, Q3)	32.3 (25.9, 57.3)	38 (24.7, 98.0)	0.245	-		-	-
Tbil, μmol/L (Q1, Q3)	20.5 (13.5, 60.0)	18.6 (11.7, 36.5)	0.327	-		-	-
Albumin, g/L, mean ± SD	35.4 ± 6.8	35.0 ± 4.8	0.341	-		-	-
Creatinine, μmol/L (Q1, Q3)	57.2 (50.4, 73.8)	59.2 (46.4, 71.2)	0.916	-		-	-
Etiology of BDLs, liver transplantation	7 (24.1)	6 (9.2)	0.053	2.657		0.562-12.551	0.284
Location of BDLs	-	-	0.438	-		-	-
Cystic duct	14 (48.3)	39 (60.0)	-	-		-	-
Common bile duct	9 (31.0)	11 (16.9)	-	-		-	-
Hilar bile duct	4 (13.8)	8 (12.3)	-	-		-	-
Intrahepatic bile duct	2 (6.9)	7 (10.8)	-	-		-	-
Performing ERCP within 3 weeks	9 (31.0)	41 (63.1)	0.005	0.256		0.096-0.683	0.007

OR: Odds ratio; CI: Confidence interval; ERCP: Endoscopic retrograde cholangiopancreatography; BMI: Body mass index; CCI: Charlson comorbidity index; WBC: White blood cell; ALT: Alanine aminotransferase; BDLs: Bile duct leaks; Tbil: Total bilirubin; Q1: First quartile; Q3: Third quartile.