Patient selection and operative strategies for laparoscopic intersphincteric resection without diverting stoma

Table 3 The univariate analysis and multivariate analysis of anastomotic leakage in baseline cohorts and non-diverting stoma cohorts

Variable	Baseline cohort (n = 505)				SF cohort (n = 84)
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	Odds ratio (95%CI)	P value	Odds ratio (95%CI)	P value	Odds ratio (95%CI)	P value	Odds ratio (95%CI)	P value
Sex (male vs female)	2.883 (1.310-6.343)	0.009	2.644 (1.161-6.020)	0.021	2.741 (0.673-11.159)	0.159	2.648 (0.606-11.575)	0.196
Age (≥ 60 years vs < 60 years)	0.738 (0.397-1.370)	0.336			0.707 (0.187-2.669)	0.609
BMI (≥ 25 kg/m2vs < 25 kg/m2)	1.899 (1.020-3.536)	0.043	1.716 (0.884-3.330)	0.111	2.450 (0.679-8.841)	0.171	2.678 (0.672-10.678)	0.163
Diabetes (yes vs no)	1.544 (0.684-3.485)	0.296			1.580 (0.293-8.509)	0.594
nCRT (yes vs no)	4.805 (2.429-9.502)	< 0.001	6.024 (2.830-12.822)	< 0.001	-	-
LCA retention (yes vs no)	0.068 (0.341-0.102)	0.105	0.417 (0.209-0.830)	0.013	0.393 (0.028-0.891)	0.039	0.312 (0.021-0.802)	0.027
Diverting stoma (yes vs no)	0.564 (0.273-1.167)	0.123	0.204 (0.087-0.481)	< 0.001
Maximal tumor size (> 35 mm vs ≤ 35 mm)	0.925 (0.498-1.718)	0.805			1.167 (0.311-4.376)	0.819
TNM stage (III–IV vs I-II)	1.254 (0.667-2.355)	0.482			--	--
Height of tumor from the anal verge (≤ 4 cm vs > 4 cm)	2.563 (0.986-6.658)	0.053	4.160 (1.488-11.634)	0.007	1.587 (0.183-13.780)	0.675
Vascular invasion (yes vs no)	1.433 (0.697-2.947)	0.328			1.253 (0.238-6.594)	0.790
Nerve invasion (yes vs no)	1.563 (0.740-3.303)	0.242			2.741 (0.673-11.159)	0.159	2.648 (0.606-11.575)	0.196

BMI: Body mass index; nCRT: Neoadjuvant chemotherapy; LCA: Left colic artery; SF: Stoma-free; CI: Confidence interval.